A nest of tumor-cell proliferation with necrosis at the center is evident (papillotubular carcinoma).
B:
Breast tissue (control)
C
C:
A tumor accompanied by ulceration is evident in the right breast.
D: Crude incidence and excess relative risk of breast cancer (1958-1987)
•
The crude incidence in the control, low-dose and high-dose groups (all ages) showed a dose response relationship of 4.3, 5.2 and 16.0 per 104person-years, respectively.
•
The excess relative risk was significantly higher in the young group at the time of bombing than in the old group at the time of bombing.
•
Although not shown on the graph, it is known that the excess relative risk of early breast cancer (before the age of 35) is higher in women who were less than 20 years old at the time of bombing.
[Cited and modified from Thompson DE, et al., Radiat Res 137:S17-S67, 1994]