Publication : Radiation and Humankind

 
Contents

Organizing Committee
ix

Preface
xi

Greeting
xiii

Addresses
xv

COE Program
1

International Consortium for Medical Care of Hibakusha and Radiation Life Science: a multidisciplinary program of Nagasaki University for the 21st Century Center of Excellence (COE) in Japan
M. Tomonaga
3

Keynote lectures
9

Radioadaptive response and genomic instability: a phenotypic dichotomy of genome–environment interaction
M.S. Sasaki
11

The Chernobyl Tissue Bank—integrating international research on thyroid cancer
G.A. Thomas
21

Hallmarks of radiation carcinogenesis: ignored concepts
J.E. Trosko and C.-C. Chang
31

Overview of studies on atomic bomb survivors
37

The researches at Nagasaki University on atomic bomb survivors
I. Sekine
39

The scientific program of RERF
B.G. Bennett
51

Epidemiological and molecular studies in global radio-contaminated areas
59

Current situation and future planning of molecular epidemiology of radiation health effects around Chernobyl and Semipalatinsk
S. Yamashita
61

Risk of radiogenic malignant and benign thyroid diseases for the population of the Oryol oblast after the Chernobyl accident: outcome of large-scale epidemiological studies
V.K. Ivanov, A.F. Tsyb, S.Yu. Chekin, V.S. Parshin, M.A. Maksioutov, A.S. Saenko, A.V. Sevankaev, I.A. Zamulaeva, I.K. Khvostunov, A.I. Gorski, O.V. Kaidalov and O.K. Vlasov
67

Regularities of somatic gene mutagenesis in radiation-exposed individuals
A.A. Saenko and I.A. Zamulaeva
79

Overview of research and future prospects in radiation medicine based on the current health status in Belarus
P.I. Bespalchuk, S. Kabak, E. Cherstvoy, Yu. Demidchik, B.V. Dubovik,
D.J. Romanovsky and A. Stogarov

85

Thyroid gland and radiation (Ukrainian-American Thyroid Project)
M.D. Tronko, O.O. Bobylyova, T.I. Bogdanova, O.V. Epshtein, I.A. Likhtaryov, V.V. Markov, V.A. Oliynyk, V.P. Tereshchenko, V.M. Shpak, G. Beebe, A. Bouville, A. Brill, D. Burch, D. Fink, E. Greenebaum, G. Howe, N. Luckyanov, I. Masnyk, R. McConnell, J. Robbins, T. Thomas and P. Voilleque´
91

Medical consequences of the Chernobyl Nuclear Power Plant accident in Ukraine
V.G. Bebeshko
105

Medical monitoring results of survivors with acute radiation syndrome after Chernobyl disaster
V.G. Bebeshko, A.N. Kovalenko, D.A. Belyi, D.A. Bazyka, A.A. Chumak, V.A. Sushko and V.M. Gayiday
115

Fallout exposure and health condition of the population in the Semipalatinsk region of Kazakhstan
M.K. Teleuov
123

Morphological investigation of thyroid and parathyroid glands of the population living around the Semipalatinsk Nuclear Test Site
Yu.V. Pruglo, I. Sekine, M.Yu. Pruglo and G.K. Alipov
129

Comparative investigation of somatic gene mutagenesis and apoptosis in patients with benign, malignant tumors and healthy individuals
I.A. Zamulaeva and A.A. Saenko
135

Characterization of a novel rearrangement from the ret/PTC family in a case of radiation-associated human thyroid papillary carcinoma
V.A. Saenko, T.I. Rogounovitch, Y. Shimizu-Yoshida, A.Yu. Abrosimov, E.F. Lushnikov, P.O. Roumiantsev, N. Matsumoto, M. Nakashima, S.K. Meirmanov, H. Namba, A.F. Tsyb and S. Yamashita
141

Modulation of radiosensitivity of thyroid cancer cells by inhibition of NF-nB
signaling
D.V. Starenki, H. Namba, V.A. Saenko, A. Ohtsuru and S. Yamashita
147

Selective tyrosine kinase inhibitor, STI571, inhibits growth of p53 mutant anaplastic thyroid cancer cells by inducing S–G2 transition arrest
A.P. Podtcheko, S. Tsuda, A. Ohtsuru, V.A. Saenko, J. KurebayashiI and S. Yamashita
157

Molecular features of mitochondrial DNA in radiation-associated thyroid tumors
T.I. Rogounovitch, V.A. Saenko, Y. Shimizu-Yoshida, A.Yu. Abrosimov, E.F. Lushnikov, P.O. Roumiantsev, A. Ohtsuru, H. Namba, A.F. Tsyb and S. Yamashita
163

Characteristics of mitochondrial DNA in the peripheral blood cells of residents of Kazakhstan around Semipalatinsk Nuclear Test Site
A. Hamada, N.J. Chaizhunusova, V.A. Saenko, T.I. Rogounovitch, N. Takamura and S. Yamashita
169

Involvement of Wnt pathway in thyroid cancer around Semipalatinsk Nuclear Test Site
S.K. Meirmanov, M. Nakashima, N. Takamura, M. Ito, Yu.V. Prouglo, S. Yamashita and I. Sekine
177

Research challenge in radiation biology to low level radiation
185

Ionizing radiation-induced activation of ATF-2 phosphorylation and atf3 expression is dependent on ATM and NBS kinases
J. Kool, M. Hamdi, P.D.M. Cornelissen-Steijger, C. Terleth, A.J. van der Eb and H. van Dam
187

IPersistent oxidative stress and gene expression changes in radiation-induced genomic instability
A.R. Snyder and W.F. Morgan
199

Development of photon microbeam irradiation system for radiobiology
K. Kobayashi, N. Usami, H. Maezawa, T. Hayashi, K. Hieda and K. Takakura
207

The European Masters of Science Course in Radiation Biology
K.M. Prise, B.D. Michael and K.R. Trott
213

Clusterin: a protein with multiple functions as a potential ionizing radiation exposure marker
D. Klokov, T. Criswell, L. Sampath, K.S. Leskov, K. Frinkley, S. Araki, M. Beman, D.L. Wilson and D.A. Boothman
219

Cellular radiosensitivity and cell-type-specific activation of apoptosis signaling pathways
F. Suzuki, Y. Akimoto, K. Sasai and H. Yajima
233

Radiation sensitivity and mutation position of p53
K. Okaichi, M. Ide and Y. Okumura
239

Activation of mitogen-activated protein kinase pathway by extremely low-dose ionizing radiation
K. Suzuki, S. Kodama and M. Watanabe
245

Accumulation of alanine mutant p53 at Ser15, Thr18, and Ser20 after X-irradiation
M. Yamauchi, K. Suzuki, S. Kodama and M. Watanabe
251

Radiation-induced genomic instability triggered by telomere dysfunction
S. Kodama, A. Urushibara, B. Undarmaa, N. Mukaida, K. Suzuki, M. Oshimura and M. Watanabe
255

High susceptibility to the induction of genetic instability by radiation in DNA repairdeficient cells
A. Urushibara, S. Kodama, K. Suzuki, M. Oshimura and M. Watanabe
261

Radiation-induced delayed chromosomal instability caused by large deletion
M. Ojima, K. Suzuki, S. Kodama and M. Watanabe
267

A novel radiosensitizing therapy for anaplastic thyroid cancers
A. Ohtsuru, A.P. Podtcheko, S. Tsuda, H. Namba, H. Tamura, V.A. Saenko, M. Morishita, M. Iwamatsu and S. Yamashita
273

Heat stress and gap junctions
N. Hamada, S. Kodama, K. Suzuki and M. Watanabe
277

Single-particle irradiation system to cell at National Institute of Radiological Sciences
H. Yamaguchi, Y. Sato, H. Imaseki, N. Yasuda, T. Hamano, Y. Furusawa, M. Suzuki, T. Ishikawa, T. Mori, K. Matsumoto, T. Konishi, M. Yukawa and F. Soga
281

Developing a scientific basis for radiation risk estimates: major goal of the DOE Low Dose Radiation Research Program
A.L. Brooks
287

List of participants
297

Author index 305

Keyword index 307