Leukemia

A: B:

C: D:

B : Acute lymphoid leukemia (ALL); There is a marked proliferation of small lymphoblasts.

C : Acute myeloid leukemia (AML); There is a marked proliferation of large myeloblasts.

D : Chronic myeloid leukemia (CML); There is a marked proliferation of granulocytes at various stages of maturation.

E : Crude incidence graph (166KB gif)

• Unlike solid tumors, radiation-induced leukemia occurred from around two years after the atomic bombing. Both the absolute and relative risk reached a peak shortly thereafter and then gradually decreased.
• A dose response relationship was recognized in acute lymphoid leukemia (ALL), acute myeloid leukemia (AML) and chronic myeloid leukemia (CML).
• The risk of leukemia was high in the young age group ATB.
• Adult T-cell leukemia is an endemic disease in Nagasaki and did not show a dose response relationship.
• CML is more frequent in Hiroshima than in Nagasaki because the spontaneous incidence of the disease is three times higher in the former than in the latter, and no significant difference was observed in the excess incidence of radiation-induced CML between the two cities.