This figure shows the frequency of radiation-induced chromosomal aberrations in hematopoietic stem cells in the peripheral blood (GM-CFC, BFU-E) among atomic bomb survivors exposed to a radiation dose of 100 cGy (1 centigray = 1 rad) or more. The proportion of cells with abnormal chromosome among the stem cells investigated is shown by dose. There is a positive correlation between the proportion and dose.
B
This figure shows the chromosomal abnormality in the hematopoietic stem cells in the peripheral blood (a) and abnormality in the peripheral T-lymphocyte (b) observed in a high-dose survivor. The two types show extremely similar nuclear aberrations (chromosome number 46, XY chromosome, loss or elongation of the short arm in C-group chromosomes). These facts indicate that the radiation-induced damage involves the level of totipotential hematopoietic stem cells.
[Amenomori et al., Exp. Hematol. 16, 1988]