Division of Scientific Data Registry:Tissue and Histopathology Section
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Aims of Study
 
The mission of this section is to collect, compile and preserve the clinicopathological data and tissue samples of atomic bomb survivors and to display forever evidence of the atomic bombings, disasters beyond description and unprecedented in human history. Another purpose is to establish a new methodology suitable for genetic studies on surgical materials from atomic bomb victims. After the implementation of gene extraction, the samples will be provided to genetic researchers for molecular biological analysis.


Specific Projects
 
1) Clinicopathological data, tissue/organ samples and histopathological sections obtained at autopsies conducted at Nagasaki University and the Radiation Effects Research Foundation are registered in a computer data base and are used for various studies. Investigation using this information and materials are being conducted to elucidate the relationship between atomic bomb exposure and diseases such as leukemia, malignant tumors of specific organs and nonneoplastic diseases.
2) Basic studies are now underway to establish an improved and efficient methodology for extracting DNA and/or RNA from the autopsy materials stored for many years.


Background and Scope
 
Approximately 5,000 tissue/organ samples obtained at autopsies are kept in the storage room as pathology specimens, and computers have been used to store clinicopathological information on autopsy cases. All autopsy records, including photographs, have been stored in a laser disk filing system. Moreover, an enormous volume of scientific information and pathology specimens from atomic bomb victims collected by American and Japanese investigators from immediately after the bombing were returned by the U.S. Armed Forces Institute of Pathology (AFIP) to Japan. These consist of approximately 8,000 files containing medical records and autopsy data, some 300 formalin-fixed tissue specimens, 350 paraffin-embedded blocks, 200 histological sections and 600 photographs, and all have been carefully compiled and stored.

When a system to provide genes (gene groups) to genetic specialists is established along with clinicopathological information obtained from tissue/organs of atomic bomb victims and those probably affected by irradiation, it will be possible to analyze the genetic aberrations from the viewpoint of specialized themes. Scientific information derived from these cooperative studies will help to shed light on irradiation injuries and thus to find a key to the prediction, prevention and treatment of radiation injuries.


Publications
 
2015 2009 1999  
2014 2008 1998  
2013 2007 1997  
2012 2006 1996  
2011 2005 1995  
2010 2004 1994  
  2003 1993-1989
  2002    
  2001    
  2000 PDF dataPDF
JAPANESE
  The Medical Effects of Atomic Bombing  
  Atomic Bomb Rescue and Relief Report:Dr.Takashi Nagai  
  Pathological Effects : Dr. Issei Nishimori  
  My Experience and Damages : Dr. Raisuke Shirabe  
  Dr. Raisuke Shirabe's Survey Sheets  
  Final Report of Manhattan Investigation  
  Materials and Data  
  A-bomb experiences of medical staffs  
  Exhibition Room  
  Atomic Bombing Q&A for Kids  
  Atomic Bomb Survivor Database  
  70th Memorial Ceremony  
  ABDI 50th Anniversary exhibition:Investigation just after the bombing  
  Takashi Nagai 60 years Memorial Celemony after his death  
  30th Anniversary Meeting for Establishment of Database  
  Doctors' Experience of Atomic Bombing -60th Memorial Ceremony -  
 
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Tissue and Histopathology Section
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